FAQs

什麼是NMN?

NMN(煙酰胺單核苷酸)是一種存在於我們體內的內源性物質,2013年被哈佛醫學院Paul F. Glenn生物學中心證實具有抗衰老作用。許多研究機構和科學家已經證明,NMN可以在體內迅速轉化為NAD+,從而實現延緩衰老、提高細胞活力、改善身體機能的作用。

什麼是NAD+?

NAD+(煙酰胺腺嘌呤二核苷酸)在1906年被亞瑟·哈登爵士發現,哈登爵士因此獲得了1929年諾貝爾化學獎。此後,許多諾貝爾獎得主均以研究NAD+為主。 NAD+在細胞能量代謝、為線粒體提供能量、DNA損傷修復、長壽蛋白激活、衰老調控方面具有不可替代的作用,是人類衰老的關鍵因素。

Can NMN truly achieve anti-aging?

自NMN的抗衰老功能被發現之後,美國華盛頓大學、哈佛大學醫學院,日本慶應大學、廣島大學等科研機構和科學家紛紛投入到NMN的研究中。經過大量的科學研究和動物試驗後發現,NMN可快速轉化為NAD+,並通過NAD+實現與延緩衰老有關的一系列功效。相關研究成果陸續發表在《Nature》、《Cell》、《Science》等權威科學期刊上。

服用NMN安全嗎?

NMN是人體的內源性物質,而且我們的很多食物中都含有微量的NMN。另外,全球已有多個NMN作為藥物進行臨床試驗,並且已經通過了一期人體安全性臨床試驗,進入功效驗證的階段。 2020年發表在《內分泌雜誌》上的NMN安全性臨床研究也顯示:單次口服500毫克NMN是安全的,NMN可在人體內安全有效代謝,無有害影響。

Who is suitable for NMN?  

- People who maintain and want to improve their health and skin conditions
- People who need to improve cardiovascular health
- People who is interested in anti-aging solutions 
- People who have stress and trouble sleeping
- People who need to improve concentration and memory 
- People who need overall mental and physical improvement
- People who need to improve the healthy functioning of the immune and digestive systems
- People who need to improve their fitness
• 希望改善情緒問題的

NMN膠囊每日最佳使用量?

使用Supernine NMN15000, 40歲以下建議每天服用1-2粒(250mg-500mg),40歲以上2顆及以上(500mg及以上)。

一天中何時服用NMN及怎麼服用效果最佳?

建議一天中早晨空腹的時候服用, 效果最佳。 其他時間服用雖然沒有影響效用, 但有些人晚上服用會容易造成精神亢奮。

為什麼不建議在晚上吃NMN?

服用NMN後,體內NAD+水平升高,線粒體產生能量分子ATP水平增高,會容易造成精力過旺,特別是晚上興奮程度比較高的人群,易影響睡眠。

我該由幾歲開始服用NMN?

一般建議 30歲開始服用, 因為30- 50 歲這個年紀群的 NAD+數值已下降到 ~2.74,51-70歲時更跌至 ~1.08。而許多20歲左右的年輕族群,有熬夜及煙酒習慣的, 建議可以提早開始保養。

吃NMN是否會產生依賴?

吃NMN不會有生理學依賴。因為NMN是人體本身就具有的物質,很多食物中也含有,不具有成癮性,可放心服用。

長期吃NMN有副作用嗎?如果停止服用是否還有效果?

很多天然食物、蔬菜水果中都含有NMN,長期服用無副作用,不必擔心。停止服用NMN不會對身體造成不良影響。

誰不適合服用NMN?

- People with major diseases such as cancer, multiple cysts, mental diseases, and allergic diseases are advised to consult doctors before taking NMN. 

- For some non-serious diseases requiring short-term medication, such as viral cold, gingival inflammation etc, it is recommended to suspend NMN during medication treatment and continue taking NMN after recovery. 

- NMN is not recommended for people whose NAD+ levels are already high, such as people under 18 years old, pregnant women and lactating women (infants with high NAD+ levels). 

4. 痛風患者服用NMN可能導致尿酸升高,不建議服用。

Can cancer patients take NMN?  

NMN是為了補充人體NAD+水平,癌症患者由於每個人的情況各不相同,是否可以服用因人而異,建議先詢問醫生,謹遵醫囑。

NMN能否和降血糖藥、降血壓藥一起服用?

研究表明,長期服用NMN對穩定血壓和改善胰島素的敏感性有幫助,建議NMN和降血壓藥、降血糖藥的服用時間錯開2小時以上。同時每天監測血壓、血糖,如有所降低,可經醫生同意後減少藥物的服用量。

血壓偏低能吃NMN嗎?

NMN不是降壓藥,它是通過補充NAD+來實現各種功能,高血壓人群吃NMN後有助於血壓穩定,是因為體內NAD+水平提升後各種機能開始恢復。目前沒有任何科學研究發現NMN對低血壓有什麼不良反應,可以吃。 

Can I take NMN during a cold?  

The common cold does not affect, and NMN can be taken normally.  

Can women take NMN during menstrual period?    

一般來說,女性生理期是可以吃NMN的。但是如果本身患有婦科炎症,建議生理期停止服用。

With so many NMN products in the market, why choose Supernine?

Supernine is based in the United States and all products are certified by NSF (the United States National Health Certification), HACCP, ISO international standardization certification of the factory manufacturing, and comply with FDA regulations of cGMP regulations, in addition, it is undergoing the STC testing and obtaining product quality certification in Hong Kong. 100% free of gluten, nuts and dairy products. No artificial flavors or preservatives. NMN products produced by Supernine contain up to 99.5% pure NMN. Supernine offers the best value for money per mg.

How long does Supernine NMN take see results?  

Supernine NMN 的具體效果會在不同個體中會有不同的呈現方式。 • 問題體質者7-10天左右會有所改善,最先體現在睡眠狀態逐漸變好。 • 正常體質通常在 2 - 3 週左右精神狀態方面有所改善,長期服用能使身體各項機能逐步改善。

NMN開封後,要放冰箱保存嗎?

不需要,冰箱內的濕度偏高,反而不利於NMN的存放。 NMN產品拆封後,放置於陰涼乾燥處即可。

Can take NMN causing body internal heat* which leads to canker sore or oral ulcer?  

The situation of increasing internal heat varies from person to person. Since the mitochondria produce more energy molecules called ATP and consume more B vitamins after the NAD+ level is raised, individual users may experience an initial reaction of internal heat. In addition, NMN activates glands in the stomach, spleen, and kidney, while the peripheral tissues of the body are still sluggish and aging, so there is a transient internal and external imbalance in the initial stage of NMN's action. At this time just need to supplement more water, increase exercise can relieve.

You can also start with one pill and gradually increase the dosage as your body adjusts to it. NMN itself does not cause internal heat, which is because the body's original metabolic level is relatively low. After taking NMN, mitochondrial function improves in a short time, and the body ADAPTS to the response of the process, so there is no need to worry. 

 *Excessive internal heat is a concept in traditional Chinese medicine. Normally people with excessive internal heat would easily get inflamed, sore throat, toothache, acnes, canker sore, and ulcer.

吃NMN後為什麼小便次數會增多?

NMN有助於提昇機體的新陳代謝水平,這會使身體對水分的需求增加,從而發生口渴的現象,而喝水過多自然跑廁所也會更頻繁一些。

網上報導說NMN會誘發細胞癌變,真的嗎?

聲稱NMN誘發癌症的報告屬於斷章取義,新聞裡提到的文章的原意是說:給動物癌細胞模型補充NAD+,癌細胞會長得更快。但是並不意味著,給正常細胞補充NMN會使其變成癌細胞。恰恰相反,有多篇文獻都闡述了給正常細胞補充NMN,反而會提高自身的免疫力。

是否喝茶和咖啡,會影響NMN功效嗎?

喝茶和咖啡有助於NMN的吸收轉化,茶多酚和咖啡因都是NMN的激活成分。

What are the advantages of NMN enterolysis technology?  

根據2019年一月《科學》雜誌專業論文顯示,小腸細胞上有slc12a8轉運體專門負責轉運NMN進入細胞,然後隨著血液循環,被身體各個器管和組織的細胞利用吸收,不會被氧化降解。 Slc12a8在小腸中的含量最高,是其它器官的10倍-100倍,所以小腸才是NMN的最佳吸收場所。通過腸溶吸收,避免被胃酸分解的情況下,NMN的吸收效果能得到數倍的提升。

Can you take NMN products to relieve from the effect of alcohol and protect the liver?  

In 2018, Professor Ketan Patel's team from Cambridge, UK, published in the top academic journal Nature, found that after knocking out the ALDH2 gene in mice, the DNA became unstable because alcohol and its metabolite (acetaldehyde) failed to degrade in time. This, in turn, can lead to a marked decrease in the activity of hematopoietic stem cells and even increase the risk of cancer. 

 It's worth noting that the ALDH2 gene that was knocked out in the study, in 540 million people around the world, already carries a mutation that does not clear acetaldehyde. Also, Asians make up a large portion of the population.


     Therapy 


Test the metabolic capacity of the liver 

About 10 percent of the alcohol we drink is quickly absorbed by the mouth, stomach and small intestine through respiration and urination. The rest travels through the bloodstream to the liver. So, "cure wine" the most important is the metabolic ability of the test liver. The liver metabolizes alcohol through a complex series of transformations

1. Alcohol (ethanol) converts to acetaldehyde under the action of ADH (ethanol dehydrogenase) and NAD+ (nicotinamide adenine dinucleotide); 

2. Acetaldehyde is converted to acetic acid by ALDH2 (acetaldehyde dehydrogenase 2) and NAD+; 

3. Acetic acid enters the tricarboxylic acid cycle and, after a series of reactions, is converted to carbon dioxide and water. 

Among these, the most harmful to health is the toxic acetaldehyde, ALDH2 deletion or mutation, will make the liver to acetaldehyde metabolism pathway blocked. As a result, excess acetaldehyde is present in the liver, and when it encounters a protein, it binds forcibly to form an acetaldehyde protein adduct. 

Acetaldehyde robbed apolipoprotein, will block the transport of fat, resulting in fat backlog in the liver cells, the formation of alcoholic fatty liver; 

Acetaldehyde harms the proteins on the liver cell membrane, which is easy to induce inflammation, leading to alcoholic hepatitis; 

Acetaldehyde protein adducts also speed up the process of liver fibrosis, which, if allowed to progress, can lead to the dreaded cirrhosis of the liver. 


In fact, even for those who are heavy drinkers, long-term or excessive drinking that exceeds the liver's metabolic capacity will inevitably lead to liver damage over time. Alcohol reduces NAD+ levels in the liver We already know that NAD+ is required in the liver to metabolize alcohol. NAD+ is also known as coenzyme 1. As the "number one coenzyme", it is involved in a number of important biochemical reactions in the human body, including REDOX reaction, metabolism and DNA repair mechanism. The Sirtuins family, known as longevity proteins, are also highly dependent on NAD+. The decline in NAD+ levels in our bodies is thought to be one of the key causes of aging in humans. 

If the liver is always busy metabolizing alcohol, lower levels of NAD+ in the liver are thought to be important factors in inducing steatosis, oxidative stress, fatty liver, insulin resistance and gluconeogenesis inhibition. It seems that the wine drunk not only hurt liver, but also "urge people old". 


 Supplementary NMN 


 Helps "cure alcohol and protect liver" 

In this case, is NAD+ useful? The researchers believe that taking NMN (nicotinamide mononucleotide), a precursor of NAD+, can rapidly increase the level of NAD+ in the liver and accelerate the catabolism of alcohol, thus playing a role in rapid hangover. However, more important than "cure" is "protect the liver". In 2019, Kristofer S. Fritz et al. from the University of Colorado, USA, found that NMN can increase the level of NAD+ in the liver of experimental mice, and has a protective effect on the liver. 

When mice with alcoholic liver disease were fed 500mg/kg of NMN every other day, levels of NAD+ and a range of precursor substances returned to control levels. In addition, NMN prevented the elevation of ALT and AST, two biomarkers of liver injury in plasma, suggesting that NMN had a protective effect on alcohol-induced liver injury. Using RNA sequence analysis, they also found that ethanol significantly altered the expression of 1,778 genes, of which NMN treatment reduced the effect of ethanol on 25% (437 genes). These results suggest that NMN is of great significance in the treatment of alcoholic fatty liver disease.

How much NMN coffee can I have?  

Take 1 sachet daily, preferably in the morning to boost performance.   

Can I take NMN with other medicine?  

Yes, you can. NMN does not interact with other medications.  

Will NMN cure my illness?  

No, NMN does not cure any diseases; however it can protect our body from diseases and slow down the aging process.  

How soon will I start feeling the benefits?  

How soon NMN starts to work varies from person to person and depends on many factors: 

- Your health needs: Taken into account how health deficient you are to begin with. The more deficient you are, the longer it may take to build up your immunity. 

- The supplement’s quality: It’s important to remember that not all supplements are created equally. At Supernine, we source the highest quality bioavailable nutrients and our purity is 99.5%. 

- Your body’s absorption rate: This depends on the person, everyone has different absorption levels. 

- Your diet: Remember that supplement means “in addition to”. It’s important to pair your NMN supplements with a nutritional balanced diet and healthy exercise.

Where is the origin of the product?  

SNINE NMN products are made in the USA.   

Can product quality be guaranteed?   

是的,產品質量有保障。 我們承諾在我們的 NMN 補充劑中生產 99.5% 純度的 NMN。 已通過美國 cGMP 批准和香港 STC 測試並獲得產品質量認證。

Where can I purchase Supernine’s product?  

You can purchase our product on our official website (https://www.supernine.com), Amazon.com (USA) or at our Hong Kong flagship store.  

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