Twelve Weeks of NMN Supplementation Improves Muscle Function

Twelve Weeks of NMN Supplementation Improves Muscle Function

For the first time, a clinical study in older men shows that taking NMN increases blood NAD+ levels and improves various indicators of muscle strength and performance.

Animal studies have shown that administering the precursor molecule nicotinamide mononucleotide (NMN) elevates nicotinamide adenine dinucleotide (NAD+) levels. Interestingly, age-related NAD+ level reductions have been linked to cardiovascular, neurodegenerative, and metabolic diseases along with reduced muscle function, which NMN supplementation ameliorates – at least in rodents. So, how can we figure out whether NMN supplementation helps with these age-related conditions in humans?

Yamauchi and colleagues from the University of Tokyo released a non-peer reviewed journal article in Research Square showing that orally treating men over age 65 with 250 mg per day of NMN significantly increased their NAD+ levels and improved their muscle performance. Although there were no significant improvements in cognition, NMN supplementation partially improved the auditory capacity of elderly people. Findings from the study add more evidence that NMN’s healthy aging benefits seen in animals like rodents translate to humans.

Taking NMN for 12-weeks is Well-Tolerated

Before Yamauchi and colleagues tested how effective NMN is at improving muscle function in aged men, the research team wanted to know whether taking it is safe. The research team looked at common blood chemistry measurements indicative of toxicity that included liver enzymes and markers of kidney function after 12 weeks of daily NMN usage. Importantly, the lab results were unaltered in the group of men who took NMN compared to those that did not, indicating that taking NMN is well-tolerated.

Oral NMN Increases NAD+ Levels in People

Since previous research has shown that NMN supplementation increases blood NAD+ levels in aged rodents and that these higher NAD+ levels correlate with improved disease conditions, Yamauchi and colleagues tested whether NMN supplementation increases NAD+ in aged men. They found that the 12-week NMN supplementation substantially increased blood NAD+ levels, providing the first results from any study showing that NMN increases blood NAD+ in humans.

NMN Enhances Muscle Performance in Men Age 65 and Older

To find out whether these NMN-induced NAD+ level elevations drive improved physical function, Yamauchi and colleagues tested muscle strength and performance. They found that NMN significantly improved several indicators of muscle strength and performance: walking speed, grip strength, and the number of times the participants could stand up from a chair in 30 seconds. Their results demonstrate that oral NMN supplementation for 12 weeks improves muscle strength and performance in healthy, older men.