Overall, rejuvenation procedures provide promising prospects to reverse people’s biological ages, thereby prolonging life and improving health. However, many of the biological underpinnings of rejuvenation remain unknown, and the present adverse effects generated by some of these therapies (especially reprogramming) prohibit their widespread implementation. Existing methods, such as lowering the dose and regularly monitoring key statistics, can assist to mitigate these side effects.
However, in the future, extensive multi-modal assessments of the common aspects of present and emerging rejuvenation therapies will be important to remove these detrimental consequences. It will eventually be feasible to assess and harness the underlying links between age-reversing techniques as more of these therapies are created and independently validated based on molecular and physiological aging biomarkers. Finally, our work at the intersection of aging, molecular profiling, high-resolution methods, and physiological assessments may pave the way for the safe and successful use of systemic rejuvenation medicines in people.