NMN Increases Telomere Length in Middle-Aged Adults

Research shows that taking nicotinamide mononucleotide (NMN) improves intestine bacteria composition and telomere length.

By the year 2050, researchers project that the global population over the age of 60 will be as high as 1.2 billion, constituting what aging scientists call the “silver tsunami.” And as people get older, the repeated DNA sequences at the ends of our chromosomes (telomeres) shorten. The erosion of telomeres leads to disorders associated with aging like metabolic disease and heart complications. 

Along these lines, inflammation from aging disrupts the balance between helpful and harmful gut bacteria, leading to inflammation that precedes age-related diseases (inflammaging). Previous studies have indicated that the nicotinamide adenine dinucleotide (NAD+) precursor, NMN, lengthens telomeres and restores healthy gut microbes. Whether NMN provides these benefits for people has not yet been examined thoroughly with clinical trials.

Wu and colleagues from the Tianjin Institute of Industrial Biotechnology have shown in a recent publication from a clinical trial that administering 500 mg/L of NMN in drinking water to 16-month-old pre-aging mice (equivalent to 45-60 year-old people) for 40 days reduces gut microbiome diversity and increases telomere length. The China-based team also found that oral NMN supplementation doubles telomere length over 90 days in human blood cells called peripheral blood mononuclear cells (PBMCs).  Given these findings, it’s possible that increasing telomere length may inhibit the onset of age-related diseases to enhance healthspan and also potentially increase lifespan.