Nanocrystals with nicotinamide riboside and resveratrol enhance NAD+ levels in mouse organs
Nicotinamide riboside (NR), as a dietary supplement, can be converted to nicotinamide adenine dinucleotide (NAD+) in cells to support metabolism and a myriad of critical cell functions. However, the efficacy of orally administered NR is limited due to its quick degradation in circulation and low bioavailability in targeted organs.
In this study, Nie and colleagues of the West China Hospital of Sichuan University fabricated nanocrystals of NR and resveratrol — an enhancer of NAD+ activity. Their article published in Drug Discovery showed that oral administration of these nanocrystals for just 8 hours significantly elevated NAD+ levels in serum and enhanced NAD+ abundance in multiple organs in mice, exhibiting an improved oral NAD+ bioavailability. Also, when mice underwent procedures that mimic heart injury, these nanocrystals protected the hearts from damage