Boosting NAD+ to Activate SIRT1

Sirtuin proteins like SIRT1 play essential roles in metabolism, DNA repair, and aging processes and depend on the crucial bioenergetic molecule NAD+ to function. NAD+ levels can be boosted by supplementing different precursor molecules, such as nicotinamide mononucleotide (NMN), in mammals like rodents and possibly humans. Also, the levels of NAD+ in cells decline throughout the body, and most likely in kidney cells, with age in various species including humans, and whether age-associated kidney scarring can be mitigated by increasing NAD+ levels with NMN to activate SIRT1 has not been thoroughly explored.
CH TRADITIONAL
CH TRADITIONAL