FAQs

什么是NMN?

NMN(烟酰胺单核苷酸)是一种存在于我们体内的内源性物质,2013年被哈佛医学院Paul F. Glenn生物学中心证实具有抗衰老作用。许多研究机构和科学家已经证明,NMN可以在体内迅速转化为NAD+,从而实现延缓衰老、提高细胞活力、改善身体机能的作用。

什么是NAD+?

NAD+(烟酰胺腺嘌呤二核苷酸)在1906年被亚瑟·哈登爵士发现,哈登爵士因此获得了1929年诺贝尔化学奖。此后,许多诺贝尔奖得主均以研究NAD+为主。 NAD+在细胞能量代谢、为线粒体提供能量、DNA损伤修复、长寿蛋白激活、衰老调控方面具有不可替代的作用,是人类衰老的关键因素。

Can NMN truly achieve anti-aging?

自NMN的抗衰老功能被发现之后,美国华盛顿大学、哈佛大学医学院,日本庆应大学、广岛大学等科研机构和科学家纷纷投入到NMN的研究中。经过大量的科学研究和动物试验后发现,NMN可快速转化为NAD+,并通过NAD+实现与延缓衰老有关的一系列功效。相关研究成果陆续发表在《Nature》、《Cell》、《Science》等权威科学期刊上。

服用NMN安全吗?

NMN是人体的内源性物质,而且我们的很多食物中都含有微量的NMN。另外,全球已有多个NMN作为药物进行临床试验,并且已经通过了一期人体安全性临床试验,进入功效验证的阶段。 2020年发表在《内分泌杂志》上的NMN安全性临床研究也显示:单次口服500毫克NMN是安全的,NMN可在人体内安全有效代谢,无有害影响。

Who is suitable for NMN?  

- People who maintain and want to improve their health and skin conditions
- People who need to improve cardiovascular health
- People who is interested in anti-aging solutions 
- People who have stress and trouble sleeping
- People who need to improve concentration and memory 
- People who need overall mental and physical improvement
- People who need to improve the healthy functioning of the immune and digestive systems
- People who need to improve their fitness
• 希望改善情绪问题的

NMN胶囊每日最佳使用量?

使用Supernine NMN15000, 40岁以下建议每天服用1-2粒(250mg-500mg),40岁以上2颗及以上(500mg及以上)。

一天中何时服用NMN及怎么服用效果最佳?

建议一天中早晨空腹的时候服用, 效果最佳。其他时间服用虽然没有影响效用, 但有些人晚上服用会容易造成精神亢奋。

为什么不建议在晚上吃NMN?

服用NMN后,体内NAD+水平升高,线粒体产生能量分子ATP水平增高,会容易造成精力过旺,特别是晚上兴奋程度比较高的人群,易影响睡眠。吃NMN是否会产生依赖?

我该由几岁开始服用NMN?

一般建议 30岁开始服用, 因为30- 50 岁这个年纪群的 NAD+数值已下降到 ~2.74,51-70岁时更跌至 ~1.08。而许多20岁左右的年轻族群,有熬夜及烟酒习惯的, 建议可以提早开始保养。

吃NMN是否会产生依赖?

吃NMN不会有生理学依赖。因为NMN是人体本身就具有的物质,很多食物中也含有,不具有成瘾性,可放心服用。

长期吃NMN有副作用吗?如果停止服用是否还有效果?

很多天然食物、蔬菜水果中都含有NMN,长期服用无副作用,不必担心。停止服用NMN不会对身体造成不良影响。

谁不适合服用NMN?

- People with major diseases such as cancer, multiple cysts, mental diseases, and allergic diseases are advised to consult doctors before taking NMN. 

- For some non-serious diseases requiring short-term medication, such as viral cold, gingival inflammation etc, it is recommended to suspend NMN during medication treatment and continue taking NMN after recovery. 

- NMN is not recommended for people whose NAD+ levels are already high, such as people under 18 years old, pregnant women and lactating women (infants with high NAD+ levels). 

4. 痛风患者服用NMN可能导致尿酸升高,不建议服用。

Can cancer patients take NMN?  

NMN是为了补充人体NAD+水平,癌症患者由于每个人的情况各不相同,是否可以服用因人而异,建议先询问医生,谨遵医嘱。

NMN能否和降血糖药、降血压药一起服用?

研究表明,长期服用NMN对稳定血压和改善胰岛素的敏感性有帮助,建议NMN和降血压药、降血糖药的服用时间错开2小时以上。同时每天监测血压、血糖,如有所降低,可经医生同意后减少药物的服用量。

血压偏低能吃NMN吗?

NMN不是降压药,它是通过补充NAD+来实现各种功能,高血压人群吃NMN后有助于血压稳定,是因为体内NAD+水平提升后各种机能开始恢复。目前没有任何科学研究发现NMN对低血压有什么不良反应,可以吃。

Can I take NMN during a cold?  

The common cold does not affect, and NMN can be taken normally.  

Can women take NMN during menstrual period?    

一般来说,女性生理期是可以吃NMN的。但是如果本身患有妇科炎症,建议生理期停止服用。

With so many NMN products in the market, why choose Supernine?

Supernine is based in the United States and all products are certified by NSF (the United States National Health Certification), HACCP, ISO international standardization certification of the factory manufacturing, and comply with FDA regulations of cGMP regulations, in addition, it is undergoing the STC testing and obtaining product quality certification in Hong Kong. 100% free of gluten, nuts and dairy products. No artificial flavors or preservatives. NMN products produced by Supernine contain up to 99.5% pure NMN. Supernine offers the best value for money per mg.

How long does Supernine NMN take see results?  

Supernine NMN 的具体效果会在不同个体中会有不同的呈现方式。 • 问题体质者7-10天左右会有所改善,最先体现在睡眠状态逐渐变好。 • 正常体质通常在 2 - 3 周左右精神状态方面有所改善,长期服用能使身体各项机能逐步改善。

NMN开封后,要放冰箱保存吗?

不需要,冰箱内的湿度偏高,反而不利于NMN的存放。 NMN产品拆封后,放置于阴凉干燥处即可。

Can take NMN causing body internal heat* which leads to canker sore or oral ulcer?  

The situation of increasing internal heat varies from person to person. Since the mitochondria produce more energy molecules called ATP and consume more B vitamins after the NAD+ level is raised, individual users may experience an initial reaction of internal heat. In addition, NMN activates glands in the stomach, spleen, and kidney, while the peripheral tissues of the body are still sluggish and aging, so there is a transient internal and external imbalance in the initial stage of NMN's action. At this time just need to supplement more water, increase exercise can relieve.

You can also start with one pill and gradually increase the dosage as your body adjusts to it. NMN itself does not cause internal heat, which is because the body's original metabolic level is relatively low. After taking NMN, mitochondrial function improves in a short time, and the body ADAPTS to the response of the process, so there is no need to worry. 

 *Excessive internal heat is a concept in traditional Chinese medicine. Normally people with excessive internal heat would easily get inflamed, sore throat, toothache, acnes, canker sore, and ulcer.

吃NMN后为什么小便次数会增多?

NMN有助于提升机体的新陈代谢水平,这会使身体对水分的需求增加,从而发生口渴的现象,而喝水过多自然跑厕所也会更频繁一些。

网上报导说NMN会诱发细胞癌变,真的吗?

声称NMN诱发癌症的报告属于断章取义,新闻里提到的文章的原意是说:给动物癌细胞模型补充NAD+,癌细胞会长得更快。但是并不意味着,给正常细胞补充NMN会使其变成癌细胞。恰恰相反,有多篇文献都阐述了给正常细胞补充NMN,反而会提高自身的免疫力。

是否喝茶和咖啡,会影响NMN功效吗?

喝茶和咖啡有助于NMN的吸收转化,茶多酚和咖啡因都是NMN的激活成分。

What are the advantages of NMN enterolysis technology?  

根据2019年一月《科学》杂志专业论文显示,小肠细胞上有slc12a8转运体专门负责转运NMN进入细胞,然后随着血液循环,被身体各个器管和组织的细胞利用吸收,不会被氧化降解。 Slc12a8在小肠中的含量最高,是其它器官的10倍-100倍,所以小肠才是NMN的最佳吸收场所。通过肠溶吸收,避免被胃酸分解的情况下,NMN的吸收效果能得到数倍的提升。

Can you take NMN products to relieve from the effect of alcohol and protect the liver?  

In 2018, Professor Ketan Patel's team from Cambridge, UK, published in the top academic journal Nature, found that after knocking out the ALDH2 gene in mice, the DNA became unstable because alcohol and its metabolite (acetaldehyde) failed to degrade in time. This, in turn, can lead to a marked decrease in the activity of hematopoietic stem cells and even increase the risk of cancer. 

 It's worth noting that the ALDH2 gene that was knocked out in the study, in 540 million people around the world, already carries a mutation that does not clear acetaldehyde. Also, Asians make up a large portion of the population.


     Therapy 


Test the metabolic capacity of the liver 

我们喝下去的酒,会被口腔、胃、小肠快速吸收,通过呼吸和排尿大概可以排出10%,其余会通过血液循环到达肝脏。所以,“解酒”最重要的就是考验肝脏的代谢能力。肝脏对酒精(乙醇)的代谢会经过一系列复杂的转化—

1. Alcohol (ethanol) converts to acetaldehyde under the action of ADH (ethanol dehydrogenase) and NAD+ (nicotinamide adenine dinucleotide); 

2. Acetaldehyde is converted to acetic acid by ALDH2 (acetaldehyde dehydrogenase 2) and NAD+; 

3. Acetic acid enters the tricarboxylic acid cycle and, after a series of reactions, is converted to carbon dioxide and water. 

Among these, the most harmful to health is the toxic acetaldehyde, ALDH2 deletion or mutation, will make the liver to acetaldehyde metabolism pathway blocked. As a result, excess acetaldehyde is present in the liver, and when it encounters a protein, it binds forcibly to form an acetaldehyde protein adduct. 

Acetaldehyde robbed apolipoprotein, will block the transport of fat, resulting in fat backlog in the liver cells, the formation of alcoholic fatty liver; 

Acetaldehyde harms the proteins on the liver cell membrane, which is easy to induce inflammation, leading to alcoholic hepatitis; 

Acetaldehyde protein adducts also speed up the process of liver fibrosis, which, if allowed to progress, can lead to the dreaded cirrhosis of the liver. 


In fact, even for those who are heavy drinkers, long-term or excessive drinking that exceeds the liver's metabolic capacity will inevitably lead to liver damage over time. Alcohol reduces NAD+ levels in the liver We already know that NAD+ is required in the liver to metabolize alcohol. NAD+ is also known as coenzyme 1. As the "number one coenzyme", it is involved in a number of important biochemical reactions in the human body, including REDOX reaction, metabolism and DNA repair mechanism. The Sirtuins family, known as longevity proteins, are also highly dependent on NAD+. The decline in NAD+ levels in our bodies is thought to be one of the key causes of aging in humans. 

If the liver is always busy metabolizing alcohol, lower levels of NAD+ in the liver are thought to be important factors in inducing steatosis, oxidative stress, fatty liver, insulin resistance and gluconeogenesis inhibition. It seems that the wine drunk not only hurt liver, but also "urge people old". 


 Supplementary NMN 


 Helps "cure alcohol and protect liver" 

In this case, is NAD+ useful? The researchers believe that taking NMN (nicotinamide mononucleotide), a precursor of NAD+, can rapidly increase the level of NAD+ in the liver and accelerate the catabolism of alcohol, thus playing a role in rapid hangover. However, more important than "cure" is "protect the liver". In 2019, Kristofer S. Fritz et al. from the University of Colorado, USA, found that NMN can increase the level of NAD+ in the liver of experimental mice, and has a protective effect on the liver. 

When mice with alcoholic liver disease were fed 500mg/kg of NMN every other day, levels of NAD+ and a range of precursor substances returned to control levels. In addition, NMN prevented the elevation of ALT and AST, two biomarkers of liver injury in plasma, suggesting that NMN had a protective effect on alcohol-induced liver injury. Using RNA sequence analysis, they also found that ethanol significantly altered the expression of 1,778 genes, of which NMN treatment reduced the effect of ethanol on 25% (437 genes). These results suggest that NMN is of great significance in the treatment of alcoholic fatty liver disease.

How much NMN coffee can I have?  

Take 1 sachet daily, preferably in the morning to boost performance.   

Can I take NMN with other medicine?  

Yes, you can. NMN does not interact with other medications.  

Will NMN cure my illness?  

No, NMN does not cure any diseases; however it can protect our body from diseases and slow down the aging process.  

How soon will I start feeling the benefits?  

How soon NMN starts to work varies from person to person and depends on many factors: 

- Your health needs: Taken into account how health deficient you are to begin with. The more deficient you are, the longer it may take to build up your immunity. 

- The supplement’s quality: It’s important to remember that not all supplements are created equally. At Supernine, we source the highest quality bioavailable nutrients and our purity is 99.5%. 

- Your body’s absorption rate: This depends on the person, everyone has different absorption levels. 

- Your diet: Remember that supplement means “in addition to”. It’s important to pair your NMN supplements with a nutritional balanced diet and healthy exercise.

Where is the origin of the product?  

SNINE NMN products are made in the USA.   

Can product quality be guaranteed?   

是的,产品质量有保障。我们承诺在我们的 NMN 补充剂中生产 99.5% 纯度的 NMN。已通过美国 cGMP 批准和香港 STC 测试并获得产品质量认证。

Where can I purchase Supernine’s product?  

You can purchase our product on our official website (https://www.supernine.com), Amazon.com (USA) or at our Hong Kong flagship store.  

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