NMN Protects Lung Structure and Function Under Stress
To test the effects of NMN on overall lung structure, Wei and colleagues treated mice with bleomycin by making them cough and then inhaling the antibiotic, which caused lung tissue destruction. When these mice were treated with NMN, they found reduced lung tissue destruction. The research team also found reduced numbers of inflammatory cells in the lungs and diminished overall lung weight of bleomycin-treated mice that were given NMN. Since treating mice with bleomycin induces lung scarring and the accumulation of lung scar tissue facilitates heavier lung weight, these results indicate that NMN treatment prevents senescence-associated lung scarring. These results provide further evidence that NMN significantly improves AEC senescence in aged mice.