NMN May Improve the Brain-Associated Blood Vessel Cell Response to Stress

NMN treatment improves brain associated blood vessel cell survival and protects against harmful stress in metabolic disorders like diabetes.

Diabetes cases continue to rise sharply worldwide. These patients are more prone to stroke with a 50% greater risk of hemorrhagic stroke—blood vessels rupturing in the brain. This is thought to be caused by the dysfunction of brain-associated blood vessel cells—endothelial cells—during diabetes development. Although scientists understand that this breakdown is caused by inflammation and cellular stress elicited by harmful oxygen ions (oxidative stress), how to treat this has remained elusive.

Luo and colleagues published an article in FEBS Open Bio providing evidence that supplementation with nicotinamide mononucleotide (NMN) protects mouse brain-associated endothelial cells from oxidative stress and functional decline. The study indicates that NMN supplementation to mouse endothelial cells also reduced cell death and improved the function of the cell’s powerhouse—the mitochondria. These findings could translate to the prevention of brain endothelial cell breakdown and ultimately hemorrhagic stroke in diabetes patients.

NMN Improves Brain Blood Vessel Cell Viability After Oxidative Stress

In their experiments, the team found that NMN protected mouse endothelial cells cultured in laboratory dishes treated with the oxidative-stress inducing molecule hydrogen peroxide. Treatment for 12, 24, and 48 hours with hydrogen peroxide resulted in progressive reductions in cell survival. Even more, additionally increasing NMN supplementation concentrations (300 to 500 µM) facilitated better cell proliferation rates. These results indicate that NMN can reverse the detrimental effects of oxidative stress on endothelial cells of the brain that arise from metabolic disorders like diabetes.