NMN Dosages and Efficacy
So, how do we know that taking NMN is safer than prolonged NSAID administration? In a study showing that supplementing with NMN improves oxygen utilization in runners, up to 1200 mg/day was well tolerated with no known side effects. Two other NMN human studies, one that showed insulin sensitivity enhancements and the other showing muscle function improvements, used 250 mg/day. The results compiled to this point show that NMN may provide better tolerability compared to NSAIDs.
Will Future Studies Help Designate NMN to Replace NSAIDs?
“We revealed that the NMN supplementation decreased COX-2 expression,” said Deng and colleagues. “These results suggest NMN replenishment is an effective approach for chronic inflammation treatment.”
The biggest hurdle left is to see whether supplementing people with NMN dampens the macrophage inflammatory response since this study was done on mouse macrophages. The next step might be testing NMN in human macrophages and seeing its effects when inflammation is induced. If the same anti-inflammatory effects translate to the human macrophages, future studies could examine NMN’s capabilities in people who need prolonged NSAID treatments. Only then can we start seriously considering using NMN as an NSAID replacement.