NMN decreases senescence marker in ovaries of mid-aged mice
The p16 protein slows cell divisions and proliferation during the progression of senescence. Recently, elevated p16 levels have been considered one of the indicators of ovarian aging. The present study showed high levels of p16 in ovarian follicles at 60 weeks. Huang and colleagues found that NMN diminished the levels of p16 in mouse ovaries. The drop in the ovary’s levels of p16 suggests that NMN alleviates ovary tissue senescence and protects it during aging.
The Jiangsu University researchers then show that the improvement to ovarian senescence by NMN treatment is likely due to the upregulation of critical cellular processes. For example, Huang and colleagues show increased mitochondria function and the recycling of cellular damage and debris (autophagy) in the ovaries of mid-aged mice exposed to long-term administration of NMN. In addition, the protein balance and the antioxidant capacity of follicles were restored, thereby keeping follicles relatively young.