NAD+ levels are altered by seizures
NAD+ deficiency is an important factor in several neurological disorders, including epilepsy. Interestingly, NAD+ treatment can suppress epileptogenesis by reducing cell death in the hippocampus of mice. So, investigating how NAD+ becomes deficient may prove helpful in developing a comprehensive approach for the effective treatment of neurological disorders like epilepsy.
CD38 levels increase during seizures
Khodaverdiana and colleagues dived into this and found that seizures in rodents induced by electrical overstimulation caused a significant decrease in NAD+ levels of cells in the hippocampus. When they looked at the levels of proteins involved in the consumption and degradation of NAD+ to find the culprits behind this NAD+ decline during epilepsy, the only protein they found to be altered was CD38, suggesting a key role for CD38 in the progression of epileptogenesis.