How Much NMN Do I Need To Take For It To Be Effective?

How Much NMN Do I Need To Take For It To Be Effective?

Most rodent studies showing NMN’s effectiveness in preventing age-related ailments use dosages of about 300 mg/kg. So, for a 75 kg (about 165 pounds) person, this would equate to 22,500 mg (22.5 g). Given the cost of NMN, this would likely cost over $100 per dose and, if taken once daily, over $35000 per year.

But larger organisms like humans don’t need such high doses to be effective. There is a scientific concept called “volume of distribution” that says rodents like mice need higher substance doses by a factor of 12.3 compared to humans. So, a 300 mg/kg dose in mice would equal a 24.39 mg/kg dose in humans with a 75 kg person needing about 1.829 grams for the same effect. Keep in mind that the 300 mg/kg dose in mice is considered a “huge” dose and that it probably provides more than enough NMN for effectiveness. The question then becomes, “How much NMN does a person need to take for it to have a significant effect?”

A study in mice showed that 100 mg/kg per day mitigated most age-related physiological decline. Based on that dosage, for an average adult weighing 62 kg (about 137 pounds), an optimal dosage would be about 500 mg per day. This calculation is based on dividing the human dosage by a factor of 12.3 to match the rodent “volume of distribution.” In the same manner, larger adults weighing 90 kg should take about 750 mg per day.

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