How Does NMN Improve Muscle Function?
Although these findings point to long-term NMN supplementation promoting overall muscle health, there’s no evidence as to how this all works. What’s more, the study was performed in a small group of healthy older men. To be more certain of the main conclusions that NMN can boost NAD+ levels and improve muscle strength and performance in people, these studies need to be replicated in a larger group of adults that also includes women. Nevertheless, this is a step in the right direction for NMN to be considered a clinically proven anti-aging agent, as this study is a promising indicator that some of the anti-aging effects of NMN seen in rodents may extend to humans.
What’s more, the 250 mg per day dosage used has been applied in another study showing that NMN improves muscle insulin sensitivity in older women. So, 250 mg per day may give an effective dose in older people, but a study in Japanese men showed that up to 500 mg is well-tolerated. The question, therefore, remains as to whether further benefits could be seen with higher doses that are safely tolerated.