NMN (Nicotinamide mononucleotide) is an endogenous substance which exists in our bodies and was proved to have anti-aging effects in 2013 by Paul F. Glenn Center of Aging Biology at Harvard Medical School. Many research institutions and scientists have proved that NMN can be quickly transformed into NAD+ in the body which lead to realizing the effect of delaying aging, improving cell vitality, and improving body functions.
NAD+ (Nicotinamide adenine dinucleotide) was first discovered in 1906 by Mr. Arthur Harden. In 1929, he became Nobel Prize laureate in Chemistry for his research. Since then, many Nobel laureates performed research around NAD+. NAD+ plays an irreplaceable role in cell metabolism, mitochondria supplement, DNA repair, sirtuins activation, and aging regulation, and is a key factor determining human aging.
Since the anti-aging effects of NMN was discovered, many scientific research institutions and scientists, such as the University of Washington and Harvard Medical School in the United States; the Keio University and Hiroshima University in Japan, have successively devoted into researching NMN. Based on a large number of scientific studies and animal experiments, NMN can be rapidly transformed into NAD+ realizing a series of effects relating to anti-aging through transforming into NAD+. These related research results have been published in "The Nature", "The Cell", "The Science", and other authoritative journals.
NMN is an endogenous substance in the human body and is found in small amounts in many foods. In addition NMN has been tested as drugs in many clinical trials around the world, and they have passed Phase I human safety clinical trials and entering the stage of efficacy verification. A clinical study on the safety of NMN published in the Journal of Endocrinology in 2020 also showed that 500mg of NMN is safe in a single oral administration, and NMN can be safely and effectively metabolized in the human body without any harmful effects.
- People who maintain and want to improve their health and skin conditions
- People who need to improve cardiovascular health
- People who is interested in anti-aging solutions
- People who have stress and trouble sleeping
- People who need to improve concentration and memory
- People who need overall mental and physical improvement
- People who need to improve the healthy functioning of the immune and digestive systems
- People who need to improve their fitness
- People who need to improve their mood and emotions
If using SNINE NMN 15000, it is recommended to take 1-2 capsules (250mg to 500mg) per day for those under 40 years of age and 2 or more capsules (500mg and above) for those over 40 years of age to get maximum results.
It is recommended to take it early in the day on an empty stomach for best results. Taking on other times during the day would not affect the effectiveness, but some people may feel more alive and energetic when they take it at night.
After taking NMN, the level of NAD+ in the body increases, and the level of mitochondrial energy molecule ATP increases, which is easy to cause excessive energy, especially for people with high excitement at night, and can easily affect their sleep.
It is recommended to start at the age of 30 because the NAD+ value drops to 2.74 in the 30-50 age range, and 1.08 in the 51-70 age range. However, nowadays, many young people in their 20s begin to stay up late, smoke, and drink, therefore it is suggested to start supplementing NMN early to maintain overall health.
There is no physiological dependence on NMN because NMN is a substance inherent in the human body and also contained in many of foods. Hence, it is not addictive and can be taken at ease.
There are many natural foods, vegetables, and fruits containing NMN. There would be no side effects for long-term use. There is also no adverse effects from stopping taking NMN.
- People with major diseases such as cancer, multiple cysts, mental diseases, and allergic diseases are advised to consult doctors before taking NMN.
- For some non-serious diseases requiring short-term medication, such as viral cold, gingival inflammation etc, it is recommended to suspend NMN during medication treatment and continue taking NMN after recovery.
- NMN is not recommended for people whose NAD+ levels are already high, such as people under 18 years old, pregnant women and lactating women (infants with high NAD+ levels).
- NMN may lead to elevated uric acid in patients with gout, so it is not recommended.
NMN is to supplement the level of NAD+ in the human body. Whether it can be taken by the cancer patients varies from person to person due to the different conditions of each person. It is recommended to consult with your doctor first and follow the doctor's advice.
Studies have shown that long-term use of NMN is helpful to stabilize blood pressure and improve insulin sensitivity. It is suggested that the time of taking NMN, antihypertensive drugs and anti-diabetic drugs should be staggered by more than 2 hours. At the same time, blood pressure and blood sugar should be monitored every day. If there is a decrease, the dosage of drugs can be reduced with the consent of the doctor.
NMN is not an antihypertensive drug, although it realizes various effects through NAD+. Taking NMN helps to stabilize blood pressure in people who have hypertension, because of the various effects begin to recover after the level of NAD+ in the body is increased. Currently, no scientific studies have found any adverse effects of NMN on hypotension.
The common cold does not affect, and NMN can be taken normally.
In general, women can take NMN during their periods. However, if you suffer from gynaecological inflammation, it is recommended to stop taking it during the menstrual period.
Supernine is based in the United States and all products are certified by NSF (the United States National Health Certification), HACCP, ISO international standardization certification of the factory manufacturing, and comply with FDA regulations of cGMP regulations, in addition, it is undergoing the STC testing and obtaining product quality certification in Hong Kong. 100% free of gluten, nuts and dairy products. No artificial flavors or preservatives. NMN products produced by Supernine contain up to 99.5% pure NMN. Supernine offers the best value for money per mg.
The specific effects of Supernine NMN will manifest in different ways on different individuals. People who are experiencing healthy issues or concerns will improve in about 7-10 days. Firstly, it would reflect in the gradual improvement of their sleeping quality. People who have no existing health issue or concern usually improve their mental state in about 2-3 weeks, and in a long-term use can gradually improve various overall bodily functions.
No, the humidity in the refrigerator is high, which is not conducive to the storage of NMN. After unpacking the NMN product, place it in a cool and dry place.
The situation of increasing internal heat varies from person to person. Since the mitochondria produce more energy molecules called ATP and consume more B vitamins after the NAD+ level is raised, individual users may experience an initial reaction of internal heat. In addition, NMN activates glands in the stomach, spleen, and kidney, while the peripheral tissues of the body are still sluggish and aging, so there is a transient internal and external imbalance in the initial stage of NMN's action. At this time just need to supplement more water, increase exercise can relieve.
You can also start with one pill and gradually increase the dosage as your body adjusts to it. NMN itself does not cause internal heat, which is because the body's original metabolic level is relatively low. After taking NMN, mitochondrial function improves in a short time, and the body ADAPTS to the response of the process, so there is no need to worry.
*Excessive internal heat is a concept in traditional Chinese medicine. Normally people with excessive internal heat would easily get inflamed, sore throat, toothache, acnes, canker sore, and ulcer.
NMN helps to increase the body's metabolic level, which increases the body's demand for water, resulting in thirst, and excessive water consumption will lead to more frequent natural toilet runs.
The report alleging that NMN causes cancer was taken out of context. The original meaning of the article mentioned in the news is that the animal cancer models grow faster when supplemented with NAD+. But that does not mean that replenishing normal cells with NMN will turn them into cancer cells. On the contrary, several studies have shown that the supplementation of NMN to normal cells can actually improve the immune system.
Tea and coffee contribute to the absorption and transformation of NMN, and both tea polyphenols and caffeine are active components of NMN.
According to a study published in the January 2019 issue of the Science, the SLC12A8 transporter is responsible for transporting NMN into cells in the small intestine, where it is then absorbed by cells in various organs and tissues of the body and does not undergo oxidative degradation. SLC12A8 content is the highest in small intestine, which is 10-100 times higher than that in other organs, so small intestine is the best place for NMN absorption. The absorption effect of NMN can be enhanced several times by intestinal absorption, avoiding the decomposition of gastric acid.
In 2018, Professor Ketan Patel's team from Cambridge, UK, published in the top academic journal Nature, found that after knocking out the ALDH2 gene in mice, the DNA became unstable because alcohol and its metabolite (acetaldehyde) failed to degrade in time. This, in turn, can lead to a marked decrease in the activity of hematopoietic stem cells and even increase the risk of cancer.
It's worth noting that the ALDH2 gene that was knocked out in the study, in 540 million people around the world, already carries a mutation that does not clear acetaldehyde. Also, Asians make up a large portion of the population.
Test the metabolic capacity of the liver
About 10 percent of the alcohol we drink is quickly absorbed by the mouth, stomach and small intestine through respiration and urination. The rest travels through the bloodstream to the liver. So, "cure wine" the most important is the metabolic ability of the test liver. The liver metabolizes alcohol through a complex series of transformations
1. Alcohol (ethanol) converts to acetaldehyde under the action of ADH (ethanol dehydrogenase) and NAD+ (nicotinamide adenine dinucleotide);
2. Acetaldehyde is converted to acetic acid by ALDH2 (acetaldehyde dehydrogenase 2) and NAD+;
3. Acetic acid enters the tricarboxylic acid cycle and, after a series of reactions, is converted to carbon dioxide and water.
Among these, the most harmful to health is the toxic acetaldehyde, ALDH2 deletion or mutation, will make the liver to acetaldehyde metabolism pathway blocked. As a result, excess acetaldehyde is present in the liver, and when it encounters a protein, it binds forcibly to form an acetaldehyde protein adduct.
Acetaldehyde robbed apolipoprotein, will block the transport of fat, resulting in fat backlog in the liver cells, the formation of alcoholic fatty liver;
Acetaldehyde harms the proteins on the liver cell membrane, which is easy to induce inflammation, leading to alcoholic hepatitis;
Acetaldehyde protein adducts also speed up the process of liver fibrosis, which, if allowed to progress, can lead to the dreaded cirrhosis of the liver.
In fact, even for those who are heavy drinkers, long-term or excessive drinking that exceeds the liver's metabolic capacity will inevitably lead to liver damage over time. Alcohol reduces NAD+ levels in the liver We already know that NAD+ is required in the liver to metabolize alcohol. NAD+ is also known as coenzyme 1. As the "number one coenzyme", it is involved in a number of important biochemical reactions in the human body, including REDOX reaction, metabolism and DNA repair mechanism. The Sirtuins family, known as longevity proteins, are also highly dependent on NAD+. The decline in NAD+ levels in our bodies is thought to be one of the key causes of aging in humans. If the liver is always busy metabolizing alcohol, lower levels of NAD+ in the liver are thought to be important factors in inducing steatosis, oxidative stress, fatty liver, insulin resistance and gluconeogenesis inhibition. It seems that the wine drunk not only hurt liver, but also "urge people old".
Helps "cure alcohol and protect liver"
In this case, is NAD+ useful? The researchers believe that taking NMN (nicotinamide mononucleotide), a precursor of NAD+, can rapidly increase the level of NAD+ in the liver and accelerate the catabolism of alcohol, thus playing a role in rapid hangover. However, more important than "cure" is "protect the liver". In 2019, Kristofer S. Fritz et al. from the University of Colorado, USA, found that NMN can increase the level of NAD+ in the liver of experimental mice, and has a protective effect on the liver.
When mice with alcoholic liver disease were fed 500mg/kg of NMN every other day, levels of NAD+ and a range of precursor substances returned to control levels. In addition, NMN prevented the elevation of ALT and AST, two biomarkers of liver injury in plasma, suggesting that NMN had a protective effect on alcohol-induced liver injury. Using RNA sequence analysis, they also found that ethanol significantly altered the expression of 1,778 genes, of which NMN treatment reduced the effect of ethanol on 25% (437 genes). These results suggest that NMN is of great significance in the treatment of alcoholic fatty liver disease.
Take 1 sachet daily, preferably in the morning to boost performance.
Yes, you can. NMN does not interact with other medications.
No, NMN does not cure any diseases; however it can protect our body from diseases and slow down the aging process.
How soon NMN starts to work varies from person to person and depends on many factors:
- Your health needs: Taken into account how health deficient you are to begin with. The more deficient you are, the longer it may take to build up your immunity.
- The supplement’s quality: It’s important to remember that not all supplements are created equally. At Supernine, we source the highest quality bioavailable nutrients and our purity is 99.5%.
- Your body’s absorption rate: This depends on the person, everyone has different absorption levels.
- Your diet: Remember that supplement means “in addition to”. It’s important to pair your NMN supplements with a nutritional balanced diet and healthy exercise.
SUPERNINE NMN products are made in the USA.
Yes, the product quality is under guarantee. It is our promise to produce 99.5% purity NMN in our NMN supplements. We have been approved by cGMP in the U.S.A. and STC tested in Hong Kong and certified for product quality.
You can purchase our product on our official website (https://www.supernine.com), Amazon.com (USA) or at our Hong Kong flagship store.