What’s Next for EVs and Muscle Regeneration?

Together, these findings suggest that Klotho transcripts within circulating EVs contribute to the systemic regulation of aged skeletal muscle regeneration. “EVs may be beneficial for boosting regenerative capacity of muscle in older individuals and improving functional recovery after an injury,” said Ambrosio.

She says that he is really excited about engineering EVs with specific cargoes so that we can dictate the responses of target cells. An enhanced mechanistic understanding of the potential of circulating EVs to attenuate, prevent, or even reverse age-related declines in skeletal muscle regeneration may help pave the way toward the development of EV-based therapeutic approaches to the benefit of the growing aging population.

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