What’s in store for future testing of NR in humans

“Collectively our data would therefore suggest that NAD+ metabolism is tightly regulated in human skeletal muscle, with short-term NAD+ precursor supplementation unable to modulate this response at rest or during and in recovery from endurance exercise,” said the authors. The chronic effects of NR on skeletal muscle NNMT content and activity, and whole-body and skeletal muscle fatty acid metabolism, warrant further investigation.
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