Rejuvenation Strategies

Rejuvenation strategies have much in common with existing longevity interventions. Although most longevity interventions cannot systemically reverse biological age like rejuvenation therapies, they attenuate certain age-related hallmarks, with essential effects such as the reduced presence of senescent cells and increased stem cell pool size and functionality.

Some rejuvenation strategies have been shown to reverse epigenetic age, increase stem cell function, reverse age-related loss of eyesight, and increase the lifespan of mouse models. Interventions usually influence age-related characteristics across multiple levels, and robust measures (biomarkers) of age-related damage at one level could be used to identify putative rejuvenation interventions.

There are all sorts of strategies for rejuvenation, ranging from the relatively innocuous like exercise and taking supplements to the more “daring” like gene therapy and organ transplantation.

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