With no adverse effect on major organs, Nie and colleagues tested whether improving NAD+ abundance with these nanocrystals protects organs against acute stress. To do so, they performed a procedure that put stress on the hearts of mice following short-term treatment with the nanocrystals and then examined heart damage and function.
One day after the procedure, the untreated mice exhibited significantly reduced pumping of the heart as compared to the mice that were not operated on. However, administration of the NR and resveratrol containing nanocrystals improved the heart’s pumping ability even more so than NR or resveratrol alone, suggesting that the operation-induced decline in heart function was ameliorated by enhancing NAD+ availability. In line with this, the procedure damaged roughly one-third of the heart, which was reduced by half with nanocrystals treatment. Taken together, their data suggested that these nanocrystals are a promising NAD+ booster that could mitigate acute heart injuries.
It will be interesting to see how these nanocrystals work in humans and whether they can aid in the effectiveness of compounds that boost NAD+ or are linked to improved health- or life-span.