NMN Reverses Inflammatory Metabolite Signature

Next, Deng and colleagues treated the macrophages with NMN and lipopolysaccharide, which induces an inflammatory state, to see whether boosting NAD+ inhibits inflammation. Upon confirming that NMN does boost NAD+ levels in macrophages, the research team went on to show that NMN antagonizes the inflammation-associated changes in metabolite levels. In other words, it partially reversed the metabolite changes seen with inflammation. These findings suggest that NMN supplementation can inhibit inflammation.

 

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