NAD+ decline drives senescence of blood vessel cells

This study showed that genetically removing CD38 or blocking CD38 with an inhibitor significantly alleviated chemically-induced vascular remodeling in mice, a model for cardiovascular disease development. When the researchers genetically deleted CD38 from mice, these animals had improvements in processes that drive cardiovascular diseases, such as high blood pressure (hypertension), increased thickness of the blood vessel wall (indicative of stiffer and less functional blood vessels) , and alterations in the level of proteins critical for maintaining blood vessel integrity. 

Their results also showed that CD38 deficiency significantly attenuated chemically-induced DNA damage and reduced the accumulation of senescence-associated markers in VSMCs in the arteries of these mice.

 

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