Japanese scientists have shown that drops containing the NAD+ precursors, NMN or NR, enhance eye gland oily secretions to prevent dry eye disease.
Within our eyelids are tiny glands that keep our eyes moist, and as we age, the production of their oily substance declines, driving a condition called dry eye disease and eye dysfunction. At the same time, testosterone levels decline in meibomian glands. Meibomian gland testosterone levels go hand-in-hand with the oily secretions, showing a link between testosterone decline and age-related dry eye disease and eye dysfunction. Researchers have been searching for ways to boost meibomian gland testosterone levels to improve the production of critical eye-coating oil to prevent evaporative eye disease and loss of eye function.
Published in Nature Aging, Kyoto University researchers show that eye drops with NAD+ precursors NMN or NR at concentrations of 100 uM improve eyelid oil secretion to mitigate dry eye disease in mice. By boosting NAD+ with NMN or NR, meibomian glands increase in size, stimulating the secretion of their oily substance to moisturize eyes. These results illustrate that treating eyes with NAD+ precursors may prevent the progression of dry eye disease during aging.