NAD+ boosting molecules can benefit healthspan and longevity and ameliorate age-related conditions through unique pathways from metabolic precursors to enzymatic regulators.
Researchers have demonstrated the crucial roles of the molecule nicotinamide adenine dinucleotide (NAD+) in health and longevity with laboratory animals like rodents, flies, and roundworms. Examples related to its benefits abound where boosting NAD+ levels improves cognition, metabolic health, and cardiovascular wellbeing in these animals during aging.
This doesn’t seem surprising given that animal and human cells require NAD+ for over 500 enzymatic reactions that regulate nearly all major biological processes. So, the question remains whether boosting NAD+ with different molecules may also help people live healthier and longer lives, and, if so, which compounds are the best suited for particular medical conditions.
Molecules that boost NAD+ levels include metabolic precursors that enhance NAD+ biosynthesis and compounds that affect specific enzymes to promote the generation or inhibit degradation of NAD+. Besides their mechanism of action, the key differences between these NAD+ boosters are their unique effects on different tissues. For instance, one booster may increase NAD+ levels primarily in skeletal muscle while another raises its levels in the liver.
So, given the tissue-specific effects of different NAD+ boosters, using them likely provides distinct physiological benefits. To explore more detail about these differences, the following will give a brief comparison of the many NAD+-boosting molecules.