Injecting NMN Enhances Mouse Immune Cell Activity
To analyze NMN’s influence on NK cells, Takeda and Okumura injected mice at various ages with NMN and evaluated the activation and cytotoxicity of NK cells. The research duo injected varying doses of 1250, 625, 313, or 125 mg/kg/day of NMN for four days into 36-week old mice and then harvested NK cells from the liver and spleen. These NK cells were then put into a dish with cancer cells at different ratios and were analyzed for cytotoxicity based on the percentage of destroyed cancer cells. These findings indicate that injecting 313 mg/kg or more of NMN enhances aged NK cell capabilities to destroy dysfunctional cells in mice.