Falling Lung NAD+ Levels During Aging
NMN is a precursor to nicotinamide adenine dinucleotide (NAD+) — a crucial molecule for metabolism and DNA health that shows reduced levels with age in many cell types and organs, including the lungs. Age-related diseases like cardiovascular ailments, neurodegenerative conditions, and metabolic impairments have all been linked to age-associated NAD+ level reductions, and research has shown that NMN alleviates various age-related diseases in mice. But whether it helps with lung aging and senescence hadn’t been explored, until now.
NMN Reduces the Buildup of Age-Associated Proteins
To figure out whether NMN prevents lung tissue aging and AEC senescence, Wei and colleagues examined its effects on levels of the two proteins p16 and p21 that are linked with aging in mice. The p16 protein slows cell divisions and proliferation during the progression of senescence, and the research team found that NMN diminished its levels in mouse lungs. The same was true for NMN’s effects on levels of p21, a protein that links DNA damage accumulation to cell proliferation cessation during senescence. The drop in the lung’s levels of p16 and p21 suggests that NMN alleviates lung tissue senescence and protects it during aging.