Let’s talk about the Difference Between these two Supplements


You may have heard of NAD (Nicotine Amide Dinucleotide) if you have been keeping up with aging and science news. NAD is a very important compound when it comes to metabolic reactions and having low levels of NAD in the body will cause early aging and decrease energy content in the cellular system.

NMN Vs NR Molecule

NMN (Nicotinamide mononucleotide) and Nicotinamide Riboside (NR) are biosynthetic precursors to NAD+, where NMN is a comparatively larger molecule than NR. Both NMN and NR have been shown to significantly increase the NAD+ levels as they are proven precursor molecules of its production by the Salvage pathway. NMN creates NAD in three steps while NR requires only two. NMR is the direct precursor of the NAD+ but it cannot go inside the cell in this form because of the presence of a phosphate group. Rather, it gets converted into NR utilizing NKR enzymes, gets into the cells, and then convert back to NMN which will then proceed for the NAD production pathway.


NMN, a Super Supplement?

NMN needs to be transported into cells by a transporter specific to NMN, such as Slc12a8. However, NR can directly access the cell, so it only requires two steps to begin creating NAD. One important thing to mention is that NR is a Vitamin while NMN is not.  NR is the largest part of NAD that can enter the cell. This is why NMN supplements turn into NR first before they can make NAD.

If you look at the studies done with NMN and NR, it is reported that NMN has enabled stronger and more diverse effects than NR. On the other hand, NR is very unstable in the bloodstream, where it quickly degrades into Vitamin B3, while NMN is very stable in the bloodstream. The gut absorbs a very little NR, and almost all NR is broken down into NAM (Nicotine Amide) by the liver before it reaches the tissues. Because of the proven characteristic of being more stable in the blood, NMN is now becoming a miraculous cure for aging disorders.

NMN supplements have shown tremendous potential to suppress age-associated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression.


We cannot evaluate NMN and NR as these two supplements have not been evaluated side by side in humans. However, the research found that 200mg of NR did not affect the durability, whereas NMN did. This suggests that NMN may offer some benefits over NR. Premature aging is no longer a life sentence, and supplementing properly with NMN, you can reclaim your body's NAD+ levels. You do not have to wait until it is too late; starting consuming proper supplements today and let’s assist you in living the life you have always wanted with our Supernine NMN supplements.

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